Living with hypothyroidism research strategy paper
Current research on hypothyroidism
The focus on biochemistry rather than patient symptom relief should be re-assessed. Showering would remove any contamination on the skin, which would reduce the chance of contamination from putting fingers in mouths etc. J Clin Endocrinol Metab. Therefore, in this study, as well as in others, 4 , 13 - 17 it has been demonstrated that children with CH might not be detected with the higher cutoff points that are usually used, and these additional diagnosed cases justify, in the present authors' opinion and in that of other authors, the reduction in the cutoff value of b-TSH. Treating patients not numbers: the benefit and burden of lowering TSH newborn screening cut-offs. Other NS programs also detected additional cases of CH with a lower cutoff value, as observed in the study by Barone et al. The prognosis for young patients who are diagnosed with thyroid cancer following an accidental release of radioactive iodine is no worse than it would be for young patients diagnosed with a non-radiation-induced form of thyroid cancer, i. Thyroid tests are also more likely to be obtained in patients with unspecific symptoms [ 37 , 38 , 39 ].
Prof Vaidya has co-authored over papers in peer-reviewed journals. A policy was adopted by endocrinologists in the s to replace thyroid extract with synthetic levothyroxine as the latter was then more consistent in its content [ 12131415 ].
It is also worth mentioning that radioiodine does not stay around in the environment for very long — it has a half-life of approximately eight days. When plotting TSH against FT4 concentrations the resulting distribution in a healthy population does not describe the familiar rectangle, but a kite-shaped area [ 43 ].
Cad Saude Publica. Update of newborn screening and therapy for congenital hypothyroidism.
Prevalence of thyroid disorders in india 2018
His research interests primarily focus on growth processes in the thyroid gland and other endocrine organs, and on issues of optimizing preoperative diagnostics of thyroid cancers with use of FNAB and ultrasound examination. Lancet Diabetes Endocrinol. In these conditions, LT4 treatment may not be superior to placebo in symptom alleviation [ 40 , 41 , 42 ]. Any diagnosis of cancer is alarming, but thyroid cancer is highly treatable, and most patients go on to live a full and normal life. Few clinical trials have been performed to compare the efficacy of the two products [ 15 ], and an exploratory RCT was conducted only in [ 16 ]. J Clin Endocrinol Metab. Despite this early chemical breakthrough in drug manufacturing, desiccated animal thyroid extract remained widely used, and even at this time some patients still regard it as the most satisfactory treatment of hypothyroidism for them [ 10 , 11 ].
Consequently, a new disease class of subclinical hypothyroidism was introduced, which is solely based on the presence of an elevated TSH while the thyroid hormones FT3 and FT4 remain within their respective reference ranges [ 26 ].
Conclusion It appears that we are witnessing a consequential historic shift in the treatment of thyroid disease, driven by over-reliance on a single laboratory parameter TSH.
Published by Elsevier Editora Ltda This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way.
Treating patients not numbers: the benefit and burden of lowering TSH newborn screening cut-offs. Thyroid dyshormonogenesis: severe hypothyroidism after normal neonatal thyroid stimulating hormone screening.
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